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Targeted Allele Detail
Symbol: Tnfrsf1atm3.2Gkl
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 3.2, George Kollias
MGI ID: MGI:5572950
Synonyms: TNFR1d, Tnfrsf1adelta
Gene: Tnfrsf1a  Location: Chr6:125349723-125362483 bp, + strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:210950
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. A second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 5. (J:210950)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  26 strains or lines available
Original:  J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory