Tnfrsf1a^tm3.2Gkl
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm3.2Gkl
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 3.2, George Kollias
• MGI ID: MGI:5572950
• Synonyms: TNFR1^d, Tnfrsf1a^delta
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm3.2Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. A second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 5. (J:210950)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 47 strains or lines available

References

• Original: J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603
• All: 3 reference(s)