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Targeted Allele Detail
Symbol: Ahrtm1.2Arte
Name: aryl-hydrocarbon receptor; targeted mutation 1.2, TaconicArtemis
MGI ID: MGI:5571477
Gene: Ahr  Location: Chr12:35497979-35534989 bp, - strand  Genetic Position: Chr12, 15.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:210360
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with the floxed human cDNA spanning exons 3 through 11. Flp-mediated recombination removed the selection marker. Cre-mediated recombination removed the human cDNA. Western blot analysis confirmed the absence of protein expression in the testis, epididymis, caudal sperm and liver. (J:210360)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ahr Mutation:  92 strains or lines available
Original:  J:210360 Hansen DA, et al., The aryl hydrocarbon receptor is important for proper seminiferous tubule architecture and sperm development in mice. Biol Reprod. 2014 Jan;90(1):8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory