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Ptgestm1.1Gaf
Targeted Allele Detail
Nomenclature
Symbol: Ptgestm1.1Gaf
Name: prostaglandin E synthase; targeted mutation 1.1, Garret FitzGerald
MGI ID: MGI:5570356
Synonyms: mPGES-1-flox
Gene: Ptges  Location: Chr2:30889471-30929863 bp, - strand  Genetic Position: Chr2, 21.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210141
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:210141)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptges Mutation:  38 strains or lines available
References
Original:  J:210141 Chen L, et al., Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013 Jan 15;127(2):233-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory