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Thtm1.1(cre/ERT2)Ddg
Targeted Allele Detail
Nomenclature
Symbol: Thtm1.1(cre/ERT2)Ddg
Name: tyrosine hydroxylase; targeted mutation 1.1, David Ginty
MGI ID: MGI:5569743
Synonyms: TH2A-CreER
Gene: Th  Location: Chr7:142892776-142899966 bp, - strand  Genetic Position: Chr7, 88.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA T2A cleavage peptide and the cre/ERT2 fusion protein coding sequence were introduced to the 3'UTR of the mouse Th gene. A FRT-PGK-EM7-NEOpolyA-FRT-loxP cassette was placed downstream of the 3'UTR region. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette, (J:239228)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Th     Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Th Mutation:  45 strains or lines available
References
Original:  J:239228 Abraira VE, et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12;168(1-2):295-310.e19
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory