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Targeted Allele Detail
Symbol: Msrb3tm1Hyk
Name: methionine sulfoxide reductase B3; targeted mutation 1, Hwa-Young Kim
MGI ID: MGI:5569504
Gene: Msrb3  Location: Chr10:120781096-120899101 bp, - strand  Genetic Position: Chr10, 68.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:206322
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 7. Western blot analysis confirmed the absence of protein expression in the heart, skeletal muscle and testis. Immunohistochemistry confirmed the absence of protein expression in the organ of Corti. (J:206322)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msrb3 Mutation:  6 strains or lines available
Original:  J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory