Ssb^tm2.1Rjma
Targeted Allele Detail

Summary

• Symbol: Ssb^tm2.1Rjma
• Name: small RNA binding exonuclease protection factor La; targeted mutation 2.1, Richard J Maraia
• MGI ID: MGI:5569491
• Synonyms: La^F
• Gene: Ssb Location: Chr2:69691906-69702190 bp, + strand Genetic Position: Chr2, 40.95 cM
• Alliance: Ssb^tm2.1Rjma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed. Flp-mediated recombination removed the FRT-flanked neomycin cassette inserted into intron 3. (J:207687)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssb Mutation: 32 strains or lines available

References

• Original: J:207687 Gaidamakov S, et al., Targeted deletion of the gene encoding the La autoantigen (Sjogren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol. 2014 Jan;34(1):123-31
• All: 2 reference(s)