Lats1^tm1.1Jfm
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1.1Jfm
• Name: large tumor suppressor; targeted mutation 1.1, James F Martin
• MGI ID: MGI:5568586
• Synonyms: Lats1^f
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1.1Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206316
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 4 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the frt-flanked neo cassette. (J:101977)

Expression

In Mice Carrying this Mutation:

48 assay results 5 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Lats1^tm1.1Jfm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 48 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 50 reference(s)