Hprt1tm4(Tek-IGF1R)Geno
Targeted Allele Detail
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Symbol: |
Hprt1tm4(Tek-IGF1R)Geno |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, Genoway |
MGI ID: |
MGI:5568544 |
Synonyms: |
hIGFREO |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm4(Tek-IGF1R)Geno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:208523
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Hprt1tm4(Tek-IGF1R)Geno expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
IGF1R (3480) |
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Mutation details: The targeting vector reconstituted the gene and inserted into the locus the promoter driving endothelium-specific expression of the human cDNA with a polyadenylation sequence followed by a core enhancer.
(J:208523)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hprt1 Mutation: |
1273 strains or lines available
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Original: |
J:208523 Imrie H, et al., Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes. 2012 Sep;61(9):2359-68 |
All: |
2 reference(s) |
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