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Tg(tetO-EGFR*)9Hev
Transgene Detail
Summary
Symbol: Tg(tetO-EGFR*)9Hev
Name: transgene insertion 9, Harold E Varmus
MGI ID: MGI:5568395
Transgene: Tg(tetO-EGFR*)9Hev  Location: unknown  
Alliance: Tg(tetO-EGFR*)9Hev page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-EGFR*)9Hev expresses 1 gene
 
Mutation detailsTetO was used to drive expression of a human EGFR cDNA modified by an in-frame deletion ofnucleotides 2239-2256 which eliminated six exon 19 amino acids between L747 and S752. (J:109092)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:109092 Politi K, et al., Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev. 2006 Jun 1;20(11):1496-510
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory