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Med23tm1.1Pkb
Targeted Allele Detail
Nomenclature
Symbol: Med23tm1.1Pkb
Name: mediator complex subunit 23; targeted mutation 1.1, Paul K Brindle
MGI ID: MGI:5568337
Synonyms: Med23flox
Gene: Med23  Location: Chr10:24869986-24913529 bp, + strand  Genetic Position: Chr10, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin cassette was placed in intron 4 and exons 5-7 of the gene were flanked by loxP sites. Transient expression of FLP recombinase in the ES cells excised the neomycin cassette, leaving floxed exons 5-7. (J:217860)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Med23 Mutation:  46 strains or lines available
Notes
The version of this allele that does not contain the neomycin selection cassette, Med23tm1Pkb, has been analyzed.
References
Original:  J:217860 Kasper LH, et al., T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One. 2014;9(7):e102076
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory