Gt(ROSA)26Sor^{tm1(cre/Esr1*)Nns}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(cre/Esr1*)Nns}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nicholas N Smithers
• MGI ID: MGI:5566525
• Synonyms: RMCM, Rosa26^MerCreMer
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(cre/Esr1*)Nns} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194830
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(cre/Esr1*)Nns} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: cDNA encoding a cre/Esr1* fusion protein (MerCreMer; cre fused to 2 mutated mouse estrogen receptor ligand binding domains) was inserted into the Gt(ROSA)26Sor locus. Details are unpublished. (J:194830)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:194830 Schweighoffer E, et al., The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway. Immunity. 2013 Mar 21;38(3):475-88
• All: 3 reference(s)