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Grptm1Jfb
Targeted Allele Detail
Nomenclature
Symbol: Grptm1Jfb
Name: gastrin releasing peptide; targeted mutation 1, James F Battey
MGI ID: MGI:5565455
Gene: Grp  Location: Chr18:65872820-65886596 bp, + strand  Genetic Position: Chr18, 38.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205122
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neo cassette. Immunostaining analysis confirmed the absence of expression in dorsal root ganglion and spinal cord neurons. (J:205122)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grp Mutation:  22 strains or lines available
References
Original:  J:205122 Zhao ZQ, et al., Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest. 2013 Nov 1;123(11):4769-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory