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Targeted Allele Detail
Symbol: Macroh2a2tm1.1Peh
Name: macroH2A.2 histone; targeted mutation 1.1, John R Pehrson
MGI ID: MGI:5565229
Synonyms: macroH2A2 KO
Gene: Macroh2a2  Location: Chr10:61738665-61784147 bp, - strand  Genetic Position: Chr10, 32.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:220524
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting vector was designed to insert a loxP-flanked PGKneo cassette upstream of exon 2 and loxP site downstream of exon 2. Mutant mice were bred with mice carrying Tg(EIIa-cre)C5379Lmgd to remove exon 2 and the neo cassette. Polymorphisms near the gene demonstrated that the targeted gene is in a genomic region derived from the 129S4/Jae parent of the embryo from which the ES cell line was generated. (J:220524)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Macroh2a2 Mutation:  12 strains or lines available
Original:  J:220524 Pehrson JR, et al., Mice without macroH2A histone variants. Mol Cell Biol. 2014 Dec;34(24):4523-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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