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Tg(KRT14-Il4)#Lsch
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-Il4)#Lsch
Name: transgene insertion, Lawrence S Chan
MGI ID: MGI:5564943
Synonyms: Il-4 Tg
Transgene: Tg(KRT14-Il4)#Lsch  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/cBy x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT14-Il4)#Lsch expresses 1 gene
 
Mutation detailsThis transgene consists of the human basal keratinocyte (keratin 14) specific promoter/enhancer, rabbit beta-globin intron, murine Il4 cDNA, and KRT14 polyA tail. RT-PCR confirmed skin expression of the transgenic mRNA. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:126285)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:126285 Chan LS, et al., Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis. J Invest Dermatol. 2001 Oct;117(4):977-83
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory