Cd72^tm1Tsub
Targeted Allele Detail

Summary

• Symbol: Cd72^tm1Tsub
• Name: CD72 antigen; targeted mutation 1, Takeshi Tsubata
• MGI ID: MGI:5563226
• Gene: Cd72 Location: Chr4:43447724-43454720 bp, - strand Genetic Position: Chr4, 23.04 cM
• Alliance: Cd72^tm1Tsub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204782
• Parent Cell Line: CMTI-2 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 1. Western blot analysis confirmed the absence of protein expression in spleen cells. (J:204782)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd72 Mutation: 29 strains or lines available

References

• Original: J:204782 Xu M, et al., Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol. 2013 Jun 1;190(11):5436-45
• All: 1 reference(s)