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Oprm1tm1.2Cgrf
Targeted Allele Detail
Summary
Symbol: Oprm1tm1.2Cgrf
Name: opioid receptor, mu 1; targeted mutation 1.2, Claire Gaveriaux-Ruff
MGI ID: MGI:5561220
Gene: Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance: Oprm1tm1.2Cgrf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207536
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed hygromycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette, exon 2 and exon 3. (J:207536)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  53 strains or lines available
References
Original:  J:207536 Weibel R, et al., Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One. 2013;8(9):e74706
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory