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Targeted Allele Detail
Symbol: Dp(16Tiam1-Il10rb)8Yey
Name: duplication, Chr 16, Y Eugene Yu 8
MGI ID: MGI:5561088
Synonyms: Dp(16)3Yey, Dp(16)8Yey, Dp(16Tiam1-Il10rb)3Yey, Ts5Yey
Gene: Dp(16Tiam1-Il10rb)8Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:208104
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutations:    Duplication, Insertion
  Dp(16Tiam1-Il10rb)8Yey involves 43 genes/genome features (Gm22933, Gm35834, Gm35774 ...) View all
Mutation detailsThis duplication was generated by recombination between two MICER clone insertions (MHPn374h24 and MHPP321i13). The 2.1 Mb duplication spans Tiam1 to Il10rb. The duplication retains the puromycin and neomycin resistance cassettes from the original MICER clones. (J:208104)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(16Tiam1-Il10rb)8Yey Mutation:  1 strain or line available
Original:  J:208104 Liu C, et al., Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice. Hum Genet. 2014 Jun;133(6):743-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory