Tg(Tmc1/mCherry)2Ajg
Transgene Detail

Summary

• Symbol: Tg(Tmc1/mCherry)2Ajg
• Name: transgene insertion 2, Andrew Griffith
• MGI ID: MGI:5560296
• Synonyms: Tg(MSMG01-526L10/Tmc1/mCherry)2Ajg, TMC1-mCherry
• Transgene: Tg(Tmc1/mCherry)2Ajg Location: unknown
• Alliance: Tg(Tmc1/mCherry)2Ajg page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Tmc1/mCherry)2Ajg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tmc1 (MGI:2151016)

• Mutation details: The transgene was created by targeted insertion of mCherry protein coding sequence into the bacterial artificial chromosome (BAC) MSMG01-526L10. The mCherry sequence was integrated at the stop codon of Tmc1, the only gene in the BAC. The integration site was not investigated. This C-terminal fusion is expressed in the sensory hair cells of the inner ear. Confocal fluorescence images of inner hair cells from transgenic mice at postnatal day 8 (P8) show the transgenic protein localizes predominantly to the tips of the shorter rows of stereocilia. Line 2 carries 7 copies of the transgene. (J:226895)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:226895 Kurima K, et al., TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Rep. 2015 Sep 8;12(10):1606-17
• All: 3 reference(s)