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Transgene Detail
Symbol: Tg(Tmc1/mCherry)2Ajg
Name: transgene insertion 2, Andrew Griffith
MGI ID: MGI:5560296
Synonyms: Tg(MSMG01-526L10/Tmc1/mCherry)2Ajg, TMC1-mCherry
Transgene: Tg(Tmc1/mCherry)2Ajg  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(Tmc1/mCherry)2Ajg expresses 1 gene
Mutation detailsThe transgene was created by targeted insertion of mCherry protein coding sequence into the bacterial artificial chromosome (BAC) MSMG01-526L10. The mCherry sequence was integrated at the stop codon of Tmc1, the only gene in the BAC. The integration site was not investigated. This C-terminal fusion is expressed in the sensory hair cells of the inner ear. Confocal fluorescence images of inner hair cells from transgenic mice at postnatal day 8 (P8) show the transgenic protein localizes predominantly to the tips of the shorter rows of stereocilia. Line 2 carries 7 copies of the transgene. (J:226895)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:226895 Kurima K, et al., TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Rep. 2015 Sep 8;12(10):1606-17
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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