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Scribtm1.2Cj
Targeted Allele Detail
Nomenclature
Symbol: Scribtm1.2Cj
Name: scribbled planar cell polarity; targeted mutation 1.2, Neal Copeland and Nancy Jenkins
MGI ID: MGI:5559570
Gene: Scrib  Location: Chr15:76047162-76069784 bp, - strand  Genetic Position: Chr15, 35.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204591
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 8. Western blot analysis confirmed the absence of protein expression in the brain. (J:204591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  32 strains or lines available
References
Original:  J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory