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Scribtm1.1Cj
Targeted Allele Detail
Nomenclature
Symbol: Scribtm1.1Cj
Name: scribbled planar cell polarity; targeted mutation 1.1, Neal Copeland and Nancy Jenkins
MGI ID: MGI:5559569
Synonyms: Scribfl
Gene: Scrib  Location: Chr15:76047162-76069784 bp, - strand  Genetic Position: Chr15, 35.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204591
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the selection cassette and left exons 2 through 8 floxed. (J:204591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  32 strains or lines available
References
Original:  J:204591 Yamben IF, et al., Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol. 2013 Dec 1;384(1):41-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory