Megf8^tm1.1Ddg
Targeted Allele Detail

Summary

• Symbol: Megf8^tm1.1Ddg
• Name: multiple EGF-like-domains 8; targeted mutation 1.1, David D Ginty
• MGI ID: MGI:5558914
• Gene: Megf8 Location: Chr7:25016589-25065342 bp, + strand Genetic Position: Chr7, 13.75 cM
• Alliance: Megf8^tm1.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The final exon was flanked by a loxP site and an FRT-flanked neomycin resistance cassette with a 3' loxP site. Cre-mediated recombination removed the selection cassette and final exon. Western blot analysis confirmed the absence of protein expression in E12.5 embryos. (J:206541)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Megf8 Mutation: 96 strains or lines available

References

• Original: J:206541 Engelhard C, et al., MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013;2:e01160
• All: 1 reference(s)