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Ifngr1tm1.2Rds
Targeted Allele Detail
Nomenclature
Symbol: Ifngr1tm1.2Rds
Name: interferon gamma receptor 1; targeted mutation 1.2, Robert D Schreiber
MGI ID: MGI:5558049
Synonyms: Ifngr1WU-
Gene: Ifngr1  Location: Chr10:19467697-19485977 bp, + strand  Genetic Position: Chr10, 8.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:206257
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette and exons 3 and 4. Flow cytometry confirmed the absence of protein expression in spleen, peripheral blood leukocytes and thymus. (J:206257)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifngr1 Mutation:  38 strains or lines available
References
Original:  J:206257 Lee SH, et al., Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-gamma receptor subunit 1 (IFNGR1). J Immunol. 2013 Oct 15;191(8):4223-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory