Tspan2^tm1Hbw
Targeted Allele Detail

Summary

• Symbol: Tspan2^tm1Hbw
• Name: tetraspanin 2; targeted mutation 1, Hauke B Werner
• MGI ID: MGI:5556057
• Gene: Tspan2 Location: Chr3:102642086-102679626 bp, + strand Genetic Position: Chr3, 45.25 cM, cytoband F3
• Alliance: Tspan2^tm1Hbw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201143
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 1 including the translation start site was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of TSPAN2 protein in purified myelin from homozygous mice. (J:201143)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan2 Mutation: 11 strains or lines available

References

• Original: J:201143 de Monasterio-Schrader P, et al., Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia. 2013 Nov;61(11):1832-47
• All: 1 reference(s)