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Tg(CAG-LARGE)126Fmu
Transgene Detail
Nomenclature
Symbol: Tg(CAG-LARGE)126Fmu
Name: transgene insertion 126, Francesco Muntoni
MGI ID: MGI:5556056
Transgene: Tg(CAG-LARGE)126Fmu  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/10 x CBA/Ca
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-LARGE)126Fmu expresses 1 gene
 
Mutation detailsThis transgene consists of a human cytomegalovirus enhancer, chicken beta-actin promoter, human LARGE fused with the V5 epitope at the C terminal end, and a rabbit beta-globin 3' flanking sequence including a polyadenylation signal. Four lines were established: 68, 76, 116, and 126. (J:168339)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:168339 Brockington M, et al., Transgenic overexpression of LARGE induces alpha-dystroglycan hyperglycosylation in skeletal and cardiac muscle. PLoS One. 2010;5(12):e14434
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory