Cadm2tm1a(KOMP)Mbp
Targeted Allele Detail
|
Symbol: |
Cadm2tm1a(KOMP)Mbp |
Name: |
cell adhesion molecule 2; targeted mutation 1a, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:5553473 |
Synonyms: |
Cadm2KO |
Gene: |
Cadm2 Location: Chr16:66452307-67417796 bp, - strand Genetic Position: Chr16, 37.96 cM
|
Alliance: |
Cadm2tm1a(KOMP)Mbp page
|
IMPC: |
Cadm2 gene page |
|
Mutant Cell Lines: |
DEPD00590_1_A03, DEPD00590_1_A09, DEPD00590_1_B06, DEPD00590_1_B08, DEPD00590_1_C03, DEPD00590_1_C08, DEPD00590_1_C09, DEPD00590_1_D04, DEPD00590_1_D09, DEPD00590_1_E02, DEPD00590_1_E07, DEPD00590_1_E08 |
Germline Transmission: |
Earliest citation of germline transmission:
J:204812
|
Parent Cell Line: |
JM8.N4 (ES Cell)
|
Strain of Origin: |
C57BL/6N
|
Project Collection: |
KOMP-CSD
|
|
Allele Type: |
|
Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
|
Insertion
Vector: L1L2_Bact_P
|
|
|
Mutation details: The L1L2_Bact_P cassette was inserted at position 66568231 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 66569064. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157064)
|
|
|
|
Original: |
J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010; |
All: |
5 reference(s) |
|