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Mapk10tm1Lewc
Targeted Allele Detail
Nomenclature
Symbol: Mapk10tm1Lewc
Name: mitogen-activated protein kinase 10; targeted mutation 1, Joseph W Lewcock
MGI ID: MGI:5551898
Gene: Mapk10  Location: Chr5:102908547-103211430 bp, - strand  Genetic Position: Chr5, 49.61 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201577
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette replaced most of exon 11. Western blot analysis confirmed the absence of protein expression in the retina. (J:201577)
Generation of the Mapk10tm1Lewc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk10 Mutation:  6 strains or lines available
References
Original:  J:201577 Huntwork-Rodriguez S, et al., JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol. 2013 Sep 2;202(5):747-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory