About   Help   FAQ
Targeted Allele Detail
Symbol: Mapk10tm1Lewc
Name: mitogen-activated protein kinase 10; targeted mutation 1, Joseph W Lewcock
MGI ID: MGI:5551898
Gene: Mapk10  Location: Chr5:102907948-103211334 bp, - strand  Genetic Position: Chr5, 49.61 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:201577
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neomycin resistance cassette replaced most of exon 11. Western blot analysis confirmed the absence of protein expression in the retina. (J:201577)
Generation of the Mapk10tm1Lewc allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk10 Mutation:  7 strains or lines available
Original:  J:201577 Huntwork-Rodriguez S, et al., JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol. 2013 Sep 2;202(5):747-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory