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Gt(ROSA)26Sortm1(Tbx1/GFP)Bem
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Tbx1/GFP)Bem
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Bernice E Morrow
MGI ID: MGI:5551717
Synonyms: Tbx1-GFPflox
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Thymic aplasia, nasal malformations, and eye, pharyngeal and ear defects in Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+ Foxg1tm1(cre)Skm/Foxg1+ mice and microcephaly, ocular and ear defects in Gt(ROSA)26Sortm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor+ Tg(Pax2-cre)1Akg/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204435
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Gt(ROSA)26Sortm1(Tbx1/GFP)Bem expresses 1 gene
 
Mutation detailsThe targeting construct inserted into the locus a splice acceptor, floxed neomycin resistance cassette with three poly adenylation sequences and a fusion of Tbx1 with GFP. (J:204435)
Generation of the Gt(ROSA)26Sortm1(Tbx1/GFP)Bem allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  572 strains or lines available
References
Original:  J:204435 Freyer L, et al., Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol. 2013 Aug 23;13(1):33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory