Card14^tm2.1Sun
Targeted Allele Detail

Summary

• Symbol: Card14^tm2.1Sun
• Name: caspase recruitment domain family, member 14; targeted mutation 2.1, John Sundberg
• MGI ID: MGI:5550459
• Synonyms: Card14^E138A
• Gene: Card14 Location: Chr11:119198594-119236201 bp, + strand Genetic Position: Chr11, 83.36 cM
• Alliance: Card14^tm2.1Sun page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:286229
• Parent Cell Line: JM8A1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Glutamic acid codon 138 was changed to an alanine codon (p.E138A) through an A-to-C point mutation, and an FRT flanked neomycin selection cassette inserted into intron 5. Subsequent breeding to an FLP1 expressing transgenic excised the neomycin selection cassette. The mutation mimics a psoriasis-associated mutation in human. (J:286229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card14 Mutation: 38 strains or lines available

References

• Original: J:286229 Sundberg JP, et al., Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity. Exp Mol Pathol. 2019;110:104286
• All: 1 reference(s)