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Tg(ACTA1-STIM1)2Jmol
Transgene Detail
Nomenclature
Symbol: Tg(ACTA1-STIM1)2Jmol
Name: transgene insertion 2, Jeffery Molkentin
MGI ID: MGI:5550399
Transgene: Tg(ACTA1-STIM1)2Jmol  Location: unknown  Genetic Position: ChrY, Syntenic
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTA1-STIM1)2Jmol expresses 1 gene
 
Mutation detailsThe human STIM1 cDNA encoding the shorter spliced form was cloned into a human ACTA1 promoter (modified with a troponin 1 element to enhance expression in slow fibers) to create a skeletal muscle-specific transgenic strain. Expression is increased approximately 6-fold in the quadriceps, and at uniformly high levels in a broad range of skeletal muscle groups. No expression is observed in the heart. The transgene is integrated on the Y chromosome in this "low expressor" line. (J:101977)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory