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Rnf31tm1.1Kiwa
Targeted Allele Detail
Nomenclature
Symbol: Rnf31tm1.1Kiwa
Name: ring finger protein 31; targeted mutation 1.1, Kazuhiro Iwai
MGI ID: MGI:5550368
Synonyms: HOIPFL
Gene: Rnf31  Location: Chr14:55591713-55603674 bp, + strand  Genetic Position: Chr14, 28.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201885
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 12. An additional loxP site was inserted downstream of exon 18. Flp-mediated recombination removed the selection cassette and left exons 12 through 14 floxed. (J:201885)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Rnf31 Mutation:  8 strains or lines available
References
Original:  J:201885 Sasaki Y, et al., Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells. EMBO J. 2013 Sep 11;32(18):2463-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory