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Mycltm1.1Kmm
Targeted Allele Detail
Nomenclature
Symbol: Mycltm1.1Kmm
Name: v-myc avian myelocytomatosis viral oncogene lung carcinoma derived; targeted mutation 1.1, Kenneth Murphy
MGI ID: MGI:5550274
Synonyms: Mycl1gfp
Gene: Mycl  Location: Chr4:122995652-123002485 bp, + strand  Genetic Position: Chr4, 57.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:206430
Parent Cell Line:  EDJ22 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector was designed to replace the first coding exon with a green fluorescent protein (GFP) sequence and a loxP-flanked neomycin resistance (neo) cassette. Mutant mice were bred with Tg(CMV-cre)1Cgn mice (on a C57BL/6 congenic background) to remove the neo selection cassette. qPCR failed to detect mRNA in mutants. GFP expression is detected in dendritic cells in both lymphoid and non-lymphoid peripheral tissues. (J:206430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mycl Mutation:  4 strains or lines available
References
Original:  J:206430 KC W, et al., L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature. 2014 Mar 13;507(7491):243-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory