Pcsk1n^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Pcsk1n^{tm1.1(KOMP)Vlcg}
• Name: proprotein convertase subtilisin/kexin type 1 inhibitor; targeted mutation 1.1, Velocigene
• MGI ID: MGI:5548481
• Gene: Pcsk1n Location: ChrX:7786061-7790649 bp, + strand Genetic Position: ChrX, 3.57 cM, cytoband A1.1
• Alliance: Pcsk1n^{tm1.1(KOMP)Vlcg} page
• IMPC: Pcsk1n gene page

Mutation origin

• Mutant Cell Line: 11614A-A7
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: Cre-mediated excision of the parental Pcsk1n^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk1n Mutation: 12 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 3 reference(s)