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Tg(tetO-AML1/ETO)8Dzh
Transgene Detail
Nomenclature
Symbol: Tg(tetO-AML1/ETO)8Dzh
Name: transgene insertion 8, Dong-Er Zhang
MGI ID: MGI:5547825
Synonyms: AML1-ETO, TgPtet-AML1-ETO
Transgene: Tg(tetO-AML1/ETO)8Dzh  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct contains a human AML1-ETO fusion protein sequence (coding for the translocation t(8;21) associated with acute myeloid leukemias (AML)) under the transcriptional control of the tetracycline transactivator responsive promoter (tetO). Inducible expression of AML1-ETO is observed in Northern and Western blot analysis. (J:64482)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Founder lines 2, 6, 7, and 13 were also established. When mice are crossed with the mice carrying the Tg(MMTVtTA)1Mam transgene, Founder lines 6, 8, and 13 express AML1-ETO in the bone marrow. These three lines have a similar pattern of expression. Founder line 7 expresses in bone marrow and peritoneal macrophages. No inducible expression is found in line 2.
References
Original:  J:64482 Rhoades KL, et al., Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood. 2000 Sep 15;96(6):2108-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory