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Transgene Detail
Symbol: Tg(tetO-AML1/ETO)8Dzh
Name: transgene insertion 8, Dong-Er Zhang
MGI ID: MGI:5547825
Synonyms: AML1-ETO, TgPtet-AML1-ETO
Transgene: Tg(tetO-AML1/ETO)8Dzh  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgenic construct contains a human AML1-ETO fusion protein sequence (coding for the translocation t(8;21) associated with acute myeloid leukemias (AML)) under the transcriptional control of the tetracycline transactivator responsive promoter (tetO). Inducible expression of AML1-ETO is observed in Northern and Western blot analysis. (J:64482)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Founder lines 2, 6, 7, and 13 were also established. When mice are crossed with the mice carrying the Tg(MMTVtTA)1Mam transgene, Founder lines 6, 8, and 13 express AML1-ETO in the bone marrow. These three lines have a similar pattern of expression. Founder line 7 expresses in bone marrow and peritoneal macrophages. No inducible expression is found in line 2.
Original:  J:64482 Rhoades KL, et al., Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood. 2000 Sep 15;96(6):2108-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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