Dnaaf4^tm1.1Jjlo
Targeted Allele Detail

Summary

• Symbol: Dnaaf4^tm1.1Jjlo
• Name: dynein axonemal assembly factor 4; targeted mutation 1.1, Joseph J LoTurco
• MGI ID: MGI:5547587
• Synonyms: Dyx1c1^flox2-4
• Gene: Dnaaf4 Location: Chr9:72866067-72880346 bp, + strand Genetic Position: Chr9, 40.08 cM, cytoband D
• Alliance: Dnaaf4^tm1.1Jjlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205312
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 4 floxed. (J:205312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnaaf4 Mutation: 19 strains or lines available

References

• Original: J:205312 Tarkar A, et al., DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep;45(9):995-1003
• All: 2 reference(s)