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Transgene Detail
Symbol: Tg(Msx2-rtTA)885Lma
Name: transgene insertion 885, Liang Ma
MGI ID: MGI:5546503
Transgene: Tg(Msx2-rtTA)885Lma  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThis transgene consists of a 187 kb BAC clone, RP24-512K19, containing the endogenous Msx2 locus and flanking sequences (134 kb upstream and 47 kb downstream of Msx2; accession number AC154808) and a modified rtTA gene that replaced part of the first exon right after the start codon, followed by a FRT-flanked neomycin cassette and polyA sequences and was made using a two-step recombineering strategy. Two founding lines were established, 885 and 888. Western blot analysis failed to detect any truncated or fusion Msx2 protein. This BAC clone contains six additional predicted genes, which may be overexpressed. (J:148502)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:148502 Lin C, et al., Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis. 2009 Apr 15;47(5):352-359
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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