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Socs7tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Socs7tm1c(EUCOMM)Wtsi
Name: suppressor of cytokine signaling 7; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5545789
Synonyms: socs7 fl
Gene: Socs7  Location: Chr11:97362435-97398542 bp, + strand  Genetic Position: Chr11, 60.96 cM
Mutation
origin
Mutant Cell Line:  EPD0021_4_A12
Germline Transmission:  Earliest citation of germline transmission: J:205551
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsAn FRT-flanked cassette with a splice acceptor, lacZ gene, neomycin resistance gene and polyadenylation sequence (en2SA-LacZ-neo-pA) followed by a 3' loxP site was inserted upstream of the second coding exon. An additional loxP site was inserted downstream of the second coding exon. Flp-mediated recombination removed the lacZ/neomycin resistance cassette and left the second coding exon floxed. (J:205551)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs7 Mutation:  18 strains or lines available
Notes
Cell line EPD0021_4_A12 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205551
References
Original:  J:205551 Simo S, et al., Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory