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Targeted Allele Detail
Symbol: Cthrc1tm1.2Suna
Name: collagen triple helix repeat containing 1; targeted mutation 1.1, Sunao Takeshita
MGI ID: MGI:5544611
Gene: Cthrc1  Location: Chr15:39076932-39087121 bp, + strand  Genetic Position: Chr15, 15.35 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:201631
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. A loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 2. RT-PCR confirmed the absence of transcript expression in the bone. (J:201631)
Generation of the Cthrc1tm1.1Suna and Cthrc1tm1.2Suna alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cthrc1 Mutation:  18 strains or lines available
Original:  J:201631 Takeshita S, et al., Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest. 2013 Sep 3;123(9):3914-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory