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Wnk1tm2.1Juha
Targeted Allele Detail
Nomenclature
Symbol: Wnk1tm2.1Juha
Name: WNK lysine deficient protein kinase 1; targeted mutation 2.1, Juliette Hadchouel
MGI ID: MGI:5544571
Synonyms: WNK1ilox
Gene: Wnk1  Location: Chr6:119923969-120038672 bp, - strand  Genetic Position: Chr6, 56.86 cM
Increased distal convoluted tubule fractional volume in Wnk1tm2.1Juha/Wnk1+ Tg(Pgk1-cre)1Lni/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200742
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site and FRT flanked pgk-neo cassette were inserted 66 bp downstream of exon 1 and an FRT3 flanked pgk-puro cassette and loxP site were inserted 93 bp upstream of exon 2. Flp mediated recombination removed the neo and puro cassettes. (J:200742)
Generation of the Wnk1tm2.1Juha allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk1 Mutation:  4 strains or lines available
References
Original:  J:200742 Vidal-Petiot E, et al., WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory