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Tg(SNCA)OVX37Rwm
Transgene Detail
Nomenclature
Symbol: Tg(SNCA)OVX37Rwm
Name: transgene insertion OVX37, Richard Wade-Martins
MGI ID: MGI:5544307
Synonyms: SNCA-OVX
Transgene: Tg(SNCA)OVX37Rwm  Location: unknown  Genetic Position: Chr4, Syntenic
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SNCA)OVX37Rwm expresses 1 gene
 
Mutation detailsThis transgene consists of a BAC carrying the complete 111-kb wild-type human SNCA locus. This line overexpresses the human protein at nearly twice the endogenous level of the mouse protein. Fluorescence in situ hybridization analysis identified a single site of integration near the centromere of chromosome 4. (J:201991)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:201991 Janezic S, et al., Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4016-25
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory