Slc16a10^m1Ingm
Chemically induced Allele Detail

Summary

• Symbol: Slc16a10^m1Ingm
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 10; mutation 1, Ingenium Pharmaceuticals
• MGI ID: MGI:5544305
• Synonyms: tat1^Y88*
• Gene: Slc16a10 Location: Chr10:39909528-40018254 bp, - strand Genetic Position: Chr10, 21.48 cM, cytoband B1
• Alliance: Slc16a10^m1Ingm page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis results in a point mutation that results in the amino acid susbtitution of a termination codon for tyrosine at position 88 (Y88*). Immunohistochemistry confirmed the absence of protein expression in the liver and kidney. (J:205101)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a10 Mutation: 36 strains or lines available

References

• Original: J:205101 Mariotta L, et al., T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control. J Physiol. 2012 Dec 15;590(Pt 24):6413-24
• All: 10 reference(s)