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Tg(Thy1-VAPB*P56S,-EGFP)D3Cai
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-VAPB*P56S,-EGFP)D3Cai
Name: transgene insertion D3, Huaibin Cai
MGI ID: MGI:5544194
Synonyms: P56S VAPB Tg
Transgene: Tg(Thy1-VAPB*P56S,-EGFP)D3Cai  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-VAPB*P56S,-EGFP)D3Cai expresses 1 gene
 
Mutation detailsThe human VAPB cDNA with a substitution of proline with serine at residue 56 (P56S) is under the control of a pan-neuronal promoter Thy1.2. Three lines were generated. qRT-PCR indicated more than 20-fold overexpression of mRNA. Protein expression was detected in the cerebral cortex, spinal cord, striatum, and hippocampus. (J:202148)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:202148 Aliaga L, et al., Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. Hum Mol Genet. 2013 Nov 1;22(21):4293-305
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory