Sirt1^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Sirt1^tm1.1Auw
• Name: sirtuin 1; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:5538566
• Synonyms: Sirt1^L2, Sirt1^tm1.1Aux
• Gene: Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Sirt1^tm1.1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5, 6, and 7 were flanked by loxP sites and an FRT flanked selection cassette was inserted. Properly targeted mice were bred to mice expressing flp recombinase in order to excise the selection cassette. (J:200083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt1 Mutation: 78 strains or lines available

References

• Original: J:200083 Mouchiroud L, et al., The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013 Jul 18;154(2):430-41
• All: 4 reference(s)