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Transgene Detail
Symbol: Tg(AVPR1A)1Bux
Name: transgene insertion 1, Joseph Buxbaum
MGI ID: MGI:5538533
Transgene: Tg(AVPR1A)1Bux  Location: unknown  
Strain of Origin:  C57BL/6 x C3H
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(AVPR1A)1Bux expresses 1 gene
Mutation detailsThe human AVPR1A BAC transgene (hAVPR1A) was created using a 182 kbp bacterial artificial chromosome RP11-715H19 (GenBank# AC025525) that includes the entire human AVPR1A gene. The BAC also contains 109 kbp upstream of the AVPR1A transcription start site and 64 kbp downstream of the AVPR1A 3' untranslated region. Founder lines 1 and 2 were established. The primary investigator reports that both founder lines have the same expression pattern, and animals from line 1 were chosen to characterize the behavior of transgenic animals. (J:211845)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:211845 Charles R, et al., Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice. Dis Model Mech. 2014 Aug;7(8):1013-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory