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Cyp2f2tm1Ding
Targeted Allele Detail
Nomenclature
Symbol: Cyp2f2tm1Ding
Name: cytochrome P450, family 2, subfamily f, polypeptide 2; targeted mutation 1, Xinxin Ding
MGI ID: MGI:5538527
Gene: Cyp2f2  Location: Chr7:27119955-27133660 bp, + strand  Genetic Position: Chr7, 15.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204727
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette with a 3' loxP site replaced exon 4 (coding exon 3). Western blot analysis confirmed the absence of protein expression in the liver, lung and nasal olfactory mucosa. (J:204727)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cyp2f2 Mutation:  12 strains or lines available
References
Original:  J:204727 Li L, et al., Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J Pharmacol Exp Ther. 2011 Oct;339(1):62-71
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory