Ano6^tm1.1Naga
Targeted Allele Detail

Summary

• Symbol: Ano6^tm1.1Naga
• Name: anoctamin 6; targeted mutation 1.1, Shigekazu Nagata
• MGI ID: MGI:5538269
• Synonyms: TMEM16F^flox
• Gene: Ano6 Location: Chr15:95688724-95872632 bp, + strand Genetic Position: Chr15, 50.66 cM
• Alliance: Ano6^tm1.1Naga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198369
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:198369)

Generation of the Ano6^tm1.1Naga allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ano6 Mutation: 81 strains or lines available

References

• Original: J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16
• All: 2 reference(s)