Atoh8^tm2.1Mlkn
Targeted Allele Detail

Summary

• Symbol: Atoh8^tm2.1Mlkn
• Name: atonal bHLH transcription factor 8; targeted mutation 2.1, Mark L Kahn
• MGI ID: MGI:5532930
• Synonyms: Atoh8^deltaex1
• Gene: Atoh8 Location: Chr6:72183161-72212561 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Atoh8^tm2.1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203454
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1. Cre mediated recombination removed the exon 1 and the neo cassette. RT-PCR confirmed loss of exon 1 containing transcripts in hearts of postnatal day 21 homozygous mice. (J:203454)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh8 Mutation: 7 strains or lines available

References

• Original: J:203454 Rawnsley DR, et al., The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. J Biol Chem. 2013 Aug 23;288(34):24429-40
• All: 1 reference(s)