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Cxcr2tm1Rmra
Targeted Allele Detail
Nomenclature
Symbol: Cxcr2tm1Rmra
Name: chemokine (C-X-C motif) receptor 2; targeted mutation 1, Richard Ransohoff
MGI ID: MGI:5532705
Synonyms: Cxcr2fl
Gene: Cxcr2  Location: Chr1:74153994-74161246 bp, + strand  Genetic Position: Chr1, 38.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204482
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:204482)
Generation of the Cxcr2tm1Rmra allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr2 Mutation:  22 strains or lines available
References
Original:  J:204482 Liu L, et al., Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2. Genesis. 2013 Aug;51(8):587-95
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory