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Targeted Allele Detail
Symbol: Hprttm349a(hs671-icre/ERT2)Ems
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 349a, Elizabeth M Simpson
MGI ID: MGI:5532502
Synonyms: Hprttm349a(Ple293-icre/ERT2)Ems, Hs671-creERT2, Ple293-icre/frt/ERT2/frt;mEMS6068
Gene: Hprt  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Mutant Cell Line:  mEMS6068
Germline Transmission:  Earliest citation of germline transmission: J:204202
Parent Cell Line:  mEMS4855.02 (ES Cell)
Strain of Origin:  B6N.Cg-Aw-J Hprtb-m3
Project Collection: EUCOMMTOOLS
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsThe transgene was designed with an HS4 insulator region, the 2129 bp Ple293 minipromoter (based on the VISTA Enhancer Browser human element hs671 (located at chr1:97,610,491-97,611,741 (Feb. 2009 (GRCh37/hg19) Assembly) within the human dihydropyrimidine dehydrogenase (DPYD) locus), a chimeric intron cassette, the iCre/ERT2 fusion gene (with F3-frt sites flanking the ERT2 sequences), the mut6-WPRE element, an SV40 early polyA signal, an additional HS4 insulator region, a human HPRT complementary sequence (containing exon 1, intron 1, exon 2, and part of intron 2), a mouse 3' Hprt homology arm, an I-Sce linearization cut site, and a mouse 5' Hprt homology arm. (J:270567)
 Tissue activity of this recombinase allele
Driver: hs671     Summary of all recombinase alleles driven by hs671.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  1274 strains or lines available
Original:  J:204202 The Pleiades Promoter and CanEuCre Project, Generation of reporter and cre-expressing targeted transgenic mice in the Hprt1 gene using human MiniPromoters that drive region- and cell-specific gene expression in the mouse brain. MGI Direct Data Submission. 2014;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory