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Itpr1tm1.1Kmik
Targeted Allele Detail
Nomenclature
Symbol: Itpr1tm1.1Kmik
Name: inositol 1,4,5-trisphosphate receptor 1; targeted mutation 1.1, Katsuhiko Mikoshiba
MGI ID: MGI:5532199
Gene: Itpr1  Location: Chr6:108213096-108551109 bp, + strand  Genetic Position: Chr6, 49.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199800
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neomycin selection cassette was inserted into intron 2 and a third loxP site was inserted into intron 3. The selection cassette was then excised from properly targeted clones by cre expression. As a result, exon 3 was flanked by loxP sites. (J:199800)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Itpr1 Mutation:  50 strains or lines available
References
Original:  J:199800 Sugawara T, et al., Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice. J Neurosci. 2013 Jul 24;33(30):12186-96
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory