Fto^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Fto^{tm1d(EUCOMM)Wtsi}
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5529920
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^{tm1d(EUCOMM)Wtsi} page
• IMPC: Fto gene page

Mutation origin

• Mutant Cell Line: EPD0103_5_A10
• Germline Transmission: Earliest citation of germline transmission: J:203742
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_gt0
• Mutation details: Flp-mediated recombination removed the FRT flanked lacZ/neomycin sequence and left exon 3 floxed. Cre-mediated recombination removed exon 3. (J:203742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:203742 Hess ME, et al., The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013 Aug;16(8):1042-8
• All: 1 reference(s)